Xiaomei He
Education
- Postdoctoral Researcher, Biochemistry and Analytical Chemistry, University of California-Riverside, 2018
- Exchange Ph.D., Chemistry, Hong Kong Baptist University, 2017
- Ph.D., Analytical Chemistry, Wuhan University, 2012
- B.S., Chemistry, Xiamen University, 2008
Research Interests
Our lab specializes in developing mass spectrometry-based proteomics and bioinformatics techniques to identify new protein-protein interactions and novel nucleic acid-binding proteins, including those that interact with G-quadruplexes, R-loops, modified RNA, and damaged DNA. Our objective is to elucidate the biochemical mechanisms and functional roles of these interactions in cells using a multi-omics approach that integrates proteomics, genomics, and bioinformatics.
Our current research is primarily focused on two key areas: 1) Deciphering the novel crosstalk between m6A modification and histone post-translational modifications within chromatin, and elucidating the biological functions of these interactions in human cells. The outcomes of this research will significantly enhance our understanding of the molecular mechanisms driving m6A-mediated epigenetic regulation in both physiological and pathological contexts, laying the groundwork for the development of effective cancer treatment strategies. 2) Identifying novel R-loop-binding proteins and investigating the impact of disease-relevant mutations in proteins or environmental exposure on these interactions in human cells. The outcome of this research will provide a biochemical basis for a better understanding of the functional roles of protein-R-loop interactions in cells, as well as offer insights into how protein mutations or environmental exposure contribute to genome instability.
Our lab is equipped to provide foundational knowledge and experimental platforms for sample preparation, data analysis in proteomics and next-generation sequencing, and biochemical studies of protein-nucleic acid interactions. We welcome opportunities for collaboration and invite you to join us!